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Synthesis and applications of tert-alkoxysiloxane linkers in solid-phase chemistry |
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| Authors: | Marco M Meloni Duncan Armour |
| Institution: | a School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK b Merck Biosciences Ltd—UK, Padge Road, Beeston NG9 2JR, UK c Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK |
| Abstract: | Straightforward syntheses of two tert-alkoxysilyl chloride functionalised resins 3 and 31 that allow facile attachment of 1°, 2°, 3° alcohols and phenols to the solid-phase have been achieved. Resin 3 displayed useful loading levels (0.7 mmol/g), and it was stable to storage in activated form. Siloxanes from reaction of 3 with alcohols and phenols were compatible with a variety of reaction conditions commonly used in solid-phase synthesis. |
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