Synthesis and inclusion ability of a bis-β-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent |
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Authors: | Sté phane Menuel,Blandine Courcot,Josias Elysé e,Alain Marsura |
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Affiliation: | a Groupe GEVSM, Unité Mixte de Recherches CNRS, Structure et Réactivité des Systèmes Moléculaires Complexes, Université Henri Poincaré-Nancy 1, 5 rue A. Lebrun, B.P. 403, F-54001 Nancy Cedex, France b Groupe SUCRES, Unité Mixte de Recherches CNRS, Structure et Réactivité des Systèmes Moléculaires Complexes, Université Henri Poincaré-Nancy 1, Campus Victor Grignard, B.P. 239, F-54506 Vandoeuvre-lès-Nancy, France c Laboratoire SPMS, UMR CNRS 8580 B236, Ecole Centrale Paris, 1, Grande Voie des Vignes, F-92295 Châtenay-Malabry, France d Laboratoire de Physique Pharmaceutique UMR 8612, Université Paris XI, Faculté de Pharmacie, 5 rue J. B. Clément, F-92296 Châtenay-Malabry Cedex, France |
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Abstract: | The synthesis of a C2-symmetric receptor including two β-cyclodextrins connected by urea linkers to a chiral diaza-crown ether organising platform is reported. This molecular system, long thought to be a potent selective carrier for chiral/achiral organic/inorganic guests at the supramolecular level, was found to be an efficient complexing tool towards the Busulfan anticancer agent. |
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Keywords: | β-Cyclodextrin Diaza-crown ether Pseudo-cryptand Busulfan Inclusion Molecular modelling |
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