Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction |
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| Authors: | Alexander V. Butin Sergey K. Smirnov Wolfgang Bender |
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| Affiliation: | a Research Institute of Heterocyclic Compounds Chemistry, Kuban State University of Technology, Moskovskaya Street 2, Krasnodar 350072, Russia
b Bayer HealthCare AG, D-51368 Leverkusen, Germany |
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| Abstract: | A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. |
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| Keywords: | Furan Recyclization Indoles |
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