| 来源不同的卵磷脂脂质体载药性能的研究 |
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| 引用本文： | 王继波,候新朴.来源不同的卵磷脂脂质体载药性能的研究[J].齐齐哈尔大学学报(自然科学版),1988(4). |
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| 作者姓名： | 王继波 候新朴 |
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| 作者单位： | 北京医科大学药学院，北京医科大学药学院 青岛医学院化学教研室 |
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| 摘 要： | 本文研究了三种不同来源的卵磷脂(蛋黄卵磷脂,大豆卵磷脂、猪脑卵磷脂)脂质体的重要载药性质:包封率、渗漏。进一步测定了三种脂质体的粘度分布,微粘度及氧化指数,並研究了脂质体结构参数与其载药性的关系。实验证明,三种卵磷脂中,蛋黄卵磷脂制成的脂质体药药性能最佳。
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| 关 键 词： | 脂质体微粘度 氧化指数 粘度分布卵磷脂 药物载体 |
STUDY ON CARRING DRUG OF LIPOSOMES COMPOSED OF DIFFERENT PHOSPHATIDYL CHOLINE SOURCES |
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| wang Jipo Hou Xinpu.STUDY ON CARRING DRUG OF LIPOSOMES COMPOSED OF DIFFERENT PHOSPHATIDYL CHOLINE SOURCES[J].Journal of Qiqihar University(Natural Science Edition),1988(4). |
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| Authors: | wang Jipo Hou Xinpu |
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| Institution: | Beijing Medical University School of pharmacy |
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| Abstract: | In the paper, we studied earring drug of liposomes composed of three different kinds of phosphatidyl cholines: encapsulation effeciency, leakage, We also studied the relationship between three kinds of liposomal physical structural parameters-microviscdsity, size distridution, size diameter chang and adility of earring drug of liposomcs.Results showed that the earring drug ability of liposomes composed of egg yolk phosphatidyl choline was the optimum. |
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| Keywords: | Liposomes microviscosity Oxidation index Size distribution Phosphatidyl choline Drug carrier |
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