| Facile synthesis and cytotoxicity of 5-C-alkylates of 20（S）- camptothecins |
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| 引用本文： | Di Zao Li Xian Dao Pan Hong Yan Liu Song Wu. Facile synthesis and cytotoxicity of 5-C-alkylates of 20（S）- camptothecins[J]. 中国化学快报, 2008, 19(10): 1202-1205. DOI: 10.1016/j.cclet.2008.07.022 |
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| 作者姓名： | Di Zao Li Xian Dao Pan Hong Yan Liu Song Wu |
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| 作者单位： | Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| 基金项目： | The authors wish to thank Feiyun company （Huangshi, Hubei, China） and Hengrui Medicine Co., Ltd. （Lianyungang, Jiangsu, China） for their kindness in supplying camptothecin, 10-hydroxycamptothecin and topotecan, respectively. |
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| 摘 要： | A series of 5-C-alkylating camptothecins have been synthesized by one-step method, and their in vitro antitumor activity was evaluated against six human cancer cell lines. The results showed that all 5-C-alkylates of camptothecins possessed poor cytotoxicity on six human cancer cell lines.
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| 关 键 词： | 喜树碱 合成作用 烷基化 抗癌作用 |
| 收稿时间： | 2008-04-25 |
Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins |
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| Di Zao Li,Xian Dao Pan,Hong Yan Liu,Song Wu. Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins[J]. Chinese Chemical Letters, 2008, 19(10): 1202-1205. DOI: 10.1016/j.cclet.2008.07.022 |
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| Authors: | Di Zao Li Xian Dao Pan Hong Yan Liu Song Wu |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China |
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| Abstract: | A series of 5-C-alkylating camptothecins have been synthesized by one-step method.and their in vitro antitumor activity was evaluated against six human cancer cell lines.The results showed that all 5-C-alkylatcs of camptothecins possessed poor cytotoxicity on six human cancer cell lines. |
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| Keywords: | Camptothecin Synthesis 5-C-Alkylate Antitumor aetivity |
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