Study on biodegradable polymers: synthesis and characterization of poly(DL-lactic acid-co-l-lysine) random copolymer |
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Authors: | Yu Liu Minlong Yuan Xianmo Deng |
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Affiliation: | Chengdu Institute of Organic Chemistry, Academia Sinica, P.O. Box 415, Chengdu 610041, China |
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Abstract: | Poly(DL-lactic acid-co-l-lysine) (PLAL) random copolymer was obtained by copolymerization of amino acid-N-carboxy anhydride with lactic acid anhydrosulphite in the presence of an initiator. The structures of the poly(DL-lactic acid-co-ε-cbz-l-lysine) and PLAL were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. Different initiators were used to initiate the ring-opening copolymerization. Good agreement between calculated and actual compositions was observed in most cases when using dibutylzinc as initiator. The solubility of PLAL was discussed. |
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Keywords: | Lactic acid anhydrosulphite Amino acid-N-carboxyl anhydride Synthesis |
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