| Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome based on NMR techniques |
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| 作者姓名： | LI Lin WANG JianNong REN JianXun XIANG JunFeng TANG YaLin LIU JianXun HANDing |
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| 作者单位： | [1]State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China; [2]Xi Yuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China |
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| 摘 要： | Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome has been performed by comparison with those of normal rats based on NMR techniques. The relative contents of formate,creatinine,2-oxoglutarate(2-OG) ,citrate,taurine,trimethylamine-N-oxide(TMAO) ,succinate and hippurate in the urine of the rats with Qi deficiency and blood stasis syndrome have been changed. These results have provided evidence for understanding the mechanism and the therapy of Qi defi-ciency and blood stasis syndrome.
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| 关 键 词： | 代谢组学 尿 大鼠 血液 核磁共振技术 |
| 收稿时间： | 11 January 2007 |
| 修稿时间： | 2007-01-11 |
Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome based on NMR techniques |
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| LI Lin WANG JianNong REN JianXun XIANG JunFeng TANG YaLin LIU JianXun HANDing.Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome based on NMR techniques[J].Chinese Science Bulletin,2007,52(22):3068-3073. |
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| Authors: | Li Lin Wang JianNong Ren JianXun Xiang JunFeng Tang YaLin Liu JianXun Han Ding |
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| Institution: | (1) State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China;(2) Xi Yuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China |
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| Abstract: | Metabonomics analysis of the urine of rats with Qi deficiency and blood stasis syndrome has been performed by comparison with those of normal rats based on NMR techniques. The relative contents of formate,creatinine,2-oxoglutarate(2-OG) ,citrate,taurine,trimethylamine-N-oxide(TMAO) ,succinate and hippurate in the urine of the rats with Qi deficiency and blood stasis syndrome have been changed. These results have provided evidence for understanding the mechanism and the therapy of Qi defi-ciency and blood stasis syndrome. |
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| Keywords: | metabonomics NMR Qi deficiency and blood stasis syndrome urine |
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