Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity |
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Authors: | Moss Steven J Martin Christine J Wilkinson Barrie |
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Institution: | Biotica Technology Ltd., Chesterford Research Park, Little Chesterford, Essex, UK CB10 1XL. steven.moss@biotica.co.uk |
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Abstract: | Modular polyketide synthases biosynthesise natural products through successive Claisen-type condensations, where one module is responsible for one round of chain extension. This review describes recent findings where this rule of co-linearity is broken, either by one module being bypassed (skipping) or through one module being used for multiple chain extension events (stuttering). |
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