|
|||||
|
|
1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers |
|
| Authors: | R J Abdel-Jalil M Übele W Ehrlichmann W Voelter H-J Machulla |
| Institution: | 8601. Chemistry Department, Faculty of Science, Hashemite University, Zarka, Jordan 8602. Radiopharmazie, PET-Zentrum, Universit?tsklinikum Tübingen, R?ntgenweg 15, D-72076 Tübingen, Germany 8603. Radiopharmazie, PET-Zentrum, Universit?tsklinikum Tübingen, R?ntgenweg 15, D-72076 Tübingen, Germany 8604. Abteilung für Physikalische Biochemie des Physiologisch-chemischen Instituts der Universit?t Tübingen, Hoppe-Seyler Strasse 4, D-72076 Tübingen, Germany 8605. Radiopharmazie, PET-Zentrum, Universit?tsklinikum Tübingen, R?ntgenweg 15, D-72076 Tübingen, Germany |
| Abstract: | Summary 1-2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-2-(2-fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-2-(2-fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence.Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and18F labeling gave the corresponding markers in 70-82% radiochemical yield. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |