New oxazole-based peptidomimetics: useful building blocks for the synthesis of orthogonally protected macrocyclic scaffolds |
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Authors: | Mann Enrique Kessler Horst |
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Affiliation: | Institut für Organische Chemie und Biochemie, Technische Universit?t München, Lichtenbergstrasse 4, D-85747 Garching, Germany. |
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Abstract: | [structure: see text] The synthesis of a new family of densely functionalized oxazole-containing amino acids is described. These building blocks were employed for preparing macrocycles containing Lys and Glu residues by a combination of solid- and solution-phase synthesis. The resulting structures are presented as orthogonally protected scaffolds for supramolecular chemistry. |
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