| A Practical Synthesis of (S)-(+)-2-(6-methoxyl-2-naphthyl) propionic Acid |
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| 作者姓名： | Hong Zhu MA Bo WANG* Qi Zhen SHI |
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| 作者单位： | Hong Zhu MA，Bo WANG*，Qi Zhen SHI Department of Chemistry，Northwest University，ShaanXi Key Laboratory of Physico-Inorganic Chemistry，Xi抋n 710068 |
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| 摘 要： | a-Arylpropionic acids are an important class of non-steroidal anti-inflammatory agents1,2. The therapeutic efficacy of this class of drugs is well demonstrated by the introduction and extensive use of more than a dozen compounds exemplified by ibuprofen, naproxen, ketoprofen and flurbiprofen etc. However, in recent years the use of enantiomerical pure drugs in chemotherapy is becoming almost mandatory for enhancing specificity of drug action and reducing the toxicity. This awareness led to …
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A Practical Synthesis of (S)-(+)-2-(6(-methoxyl-2-naphthyl) propionic Acid |
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| Hong Zhu MA,Bo WANG,Qi Zhen SHI.A Practical Synthesis of (S)-(+)-2-(6-methoxyl-2-naphthyl) propionic Acid[J].Chinese Chemical Letters,2002,13(6). |
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| Authors: | Hong Zhu MA Bo WANG Qi Zhen SHI |
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| Abstract: | A simplified procedure for enantioselective synthesis of (S)-(+)-2-(6-methoxyl-2- naphthyl) propionic acid ((S)-(+)-naproxen), starting from (6-methoxy-a-naphthyl) -1-propanone, with D-mannitol as auxiliary catalyzed by SmCl3 in onepot is described. The yield is 87.5 %(ee value 99 %). |
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| Keywords: | Auxiliary D-mannitol enantioselective synthesis onepot (S)-(+)-naproxen |
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