| 两种南海海洋真菌2508代谢产物的DNA活性研究 |
| |
| 引用本文： | 许芳a 庞冀燕a 卢秉泰a 王佳珺a 张奕a 佘志刚a L. L. P. Vrijmoed,b E. B. Gareth Jones,b 林永成,a. 两种南海海洋真菌2508代谢产物的DNA活性研究[J]. 中国化学, 2009, 27(2): 365-368. DOI: 10.1002/cjoc.200990059 |
| |
| 作者姓名： | 许芳a 庞冀燕a 卢秉泰a 王佳珺a 张奕a 佘志刚a L. L. P. Vrijmoed b E. B. Gareth Jones b 林永成 a |
| |
| 作者单位： | a中山大学化学化工学院，广州，510275 ;b香港城市大学生物化学系，香港, 999077 ; |
| |
| 摘 要： | 研究了从南海海洋真菌2508号分离得到的一种新的海洋代谢产物Xylopyridine A (1)和一个已知代谢产物xylopyrazine A (2).他们的结构由光谱数据确定。同时通过荧光淬灭实验和光谱滴定实验研究了两种化合物与DNA的结合。结果表面1显示出很强的DNA结合作用并且是通过扦插结合的，可开发用于强DNA结合剂方面的用途。
|
| 关 键 词： | 真菌；Xylopyridine A；分离；代谢产物；荧光；CT DNA结合 |
| 收稿时间： | 2008-03-06 |
| 修稿时间： | 2008-06-10 |
Two Metabolites with DNA‐Binding Affinity from the Mangrove Fungus Xylariasp. (#2508) from the South China Sea Coast |
| |
| Fang XU,Jiyan PANG,Bingtai LU,Jiajun WANG,Yi ZHANG,Zhigang SHE,L. L. P. VRIJMOED,E. B. GARETH JONES,Yongcheng LIN. Two Metabolites with DNA‐Binding Affinity from the Mangrove Fungus Xylariasp. (#2508) from the South China Sea Coast[J]. Chinese Journal of Chemistry, 2009, 27(2): 365-368. DOI: 10.1002/cjoc.200990059 |
| |
| Authors: | Fang XU Jiyan PANG Bingtai LU Jiajun WANG Yi ZHANG Zhigang SHE L. L. P. VRIJMOED E. B. GARETH JONES Yongcheng LIN |
| |
| Affiliation: | 1. School of Chemistry and Chemical Engineering, Sun Yat‐Sen University, Guangzhou, Guangdong 510275, China;2. Tel.: 0086‐020‐84039623;3. Fax: 0086‐020‐84039623;4. Department of Biology and Chemistry, City University of Hong Kong, Hongkong 999077, China |
| |
| Abstract: | A novel metabolite xylopyridine A ( 1 ), together with a known compound pyrocoll ( 2 ), was isolated from mangrove endophytic fungus Xylaria sp. (#2508) collected from the South China Sea coast. Their structures were established on the basis of spectroscopic analysis, especially 2D‐NMR. Their affinities toward calf thymus (CT) DNA were studied by fluorescence quenching and spectrophotometric titration experiments. The results indicate that 1 showes strong DNA‐binding affinity presumably via an intercalation mechanism, thus it is exploitable as strong DNA‐binders. |
| |
| Keywords: | fungus xylopyridine A isolation metabolite fluorescence CT DNA‐binding |
|
| 点击此处可从《中国化学》浏览原始摘要信息 |
|
点击此处可从《中国化学》下载全文 |
