Proton NMR relaxation studies of solid tyrosine derivatives and their mixtures with L-leucinamide. |
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Authors: | Y L Wang P S Belton H R Tang |
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Affiliation: | Institute of Food Research, Norwich Laboratory, UK. |
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Abstract: | Proton NMR relaxation time measurements were carried out on solid tyrosine derivatives: acetyl-L-tyrosine ethyl ester (Ac-Tyroet), N-carbobenzyloxy-L-tyrosine ethyl ester (CBZ-Tyroet), N-trifluoroacetyl-L-tyrosine ethyl ester (TFAc-Tyroet) and their mixtures with L-leucinamide. It was found that spin-lattice relaxation was driven mainly by methyl group rotation it low temperature for the pure solids and the mixtures. Benzene ring flipping motion and a third motion (possibly whole molecule tumbling) were found to be responsible for relaxing Ac-Tyroet and CBZ-Tyroet at high temperature. However, these motions were highly hindered in TFAc-Tyroet. Molecular tumbling motion was detected in the supercooled liquid mixtures of L-leuNH/CBZ-Tyroet and L-leuNH/Ac-Tyroet, while this motion is absent in the mixture L-leuNH/TFAc-Tyroet. The hindered motion in TFAc-Tyroet may be one of the factors affecting its ability to form a supercooled liquid with L-leucinamide. |
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