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Enantiodifferentiation through Frequency‐Selective Pure‐Shift 1H Nuclear Magnetic Resonance Spectroscopy |
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| Authors: | Laura Castañar Dr. Míriam Pérez‐Trujillo Dr. Pau Nolis Dr. Eva Monteagudo Prof. Albert Virgili Dr. Teodor Parella |
| Affiliation: | Servei de Ressonància Magnètica Nuclear and Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra (Spain), Tel: (+34)?935812291 |
| Abstract: | A frequency‐selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical‐shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents. |
| Keywords: | chemical shift homodecoupling enantioselectivity nmr spectroscopy single pulsed‐field‐gradient echo |