Macromolecule Loading into Spherical,Elliptical, Star‐Like and Cubic Calcium Carbonate Carriers |
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| Authors: | Dr Bogdan V Parakhonskiy Dr Alexey M Yashchenok Dr Senem Donatan Dr Dmitry V Volodkin Dr Francesco Tessarolo Prof Renzo Antolini Prof Helmuth Möhwald Prof Andre G Skirtach |
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| Institution: | 1. BIOtech research center, Department of Physics, University of Trento via delle Regole 101, 38123 Mattarello (Italy), Fax: (+39)?0461 283659;2. Shubnikov Institute of Crystallography Russian Academy of Science, Leninskii prospekt 59, Moscow 119333 (Russia);3. Department of Interfaces, Max‐Planck Institute of Colloids and Interfaces, Golm/Potsdam, 14476 (Germany);4. Dept Cellular Biotechnol & Biochips, AG Biofunct Coatings, Fraunhofer Institute for Biomedical Engineering, 14476 Potsdam (Germany);5. Healthcare Research and Innovation Program (IRCS), Bruno Kessler Foundation, via Sommarive 18, 38123, Povo, Trento (Italy);6. Department of Molecular Biotechnology & Center of NB‐(NanoBio)‐Photonics, 653 Coupure Links, 9000 Ghent (Belgium) |
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| Abstract: | We fabricated calcium carbonate particles with spherical, elliptical, star‐like and cubical morphologies by varying relative salt concentrations and adding ethylene glycol as a solvent to slow down the rate of particle formation. The loading capacity of particles of different isotropic (spherical and cubical) and anisotropic (elliptical and star‐like) geometries is investigated, and the surface area of such carriers is analysed. Potential applications of such drug delivery carriers are highlighted. |
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| Keywords: | adsorption calcium drug delivery nanoparticles solid‐state structures |
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