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Label‐Free Biosensing over a Wide Concentration Range with Photonic Force Microscopy
Authors:Seungjin Heo  Prof. Kipom Kim  Prof. Yong‐Hoon Cho
Affiliation:1. Graduate School of Nanoscience & Technology (WCU), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305‐701 (Republic of Korea);2. Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305‐701 (Republic of Korea);3. Graphene Research Center, KAIST Institute for the NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305‐701 (Republic of Korea)
Abstract:We present a label‐free biosensor that measures molecular interactions between biomolecules on the surface of a probe bead and substrate over a wide concentration range. This system is capable of detecting target biomolecules with concentrations varying from 10 nM to 0.1 pM , with high selectivity and sensitivity.
Keywords:biosensors  optical tweezers  photonic force microscopy  scanning force microscopy  single‐molecule studies
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