Structure and semisynthesis of platensimide A, produced by Streptomyces platensis |
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| Authors: | Herath Kithsiri B Zhang Chaowei Jayasuriya Hiranthi Ondeyka John G Zink Deborah L Burgess Bruce Wang Jun Singh Sheo B |
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| Institution: | Merck Research Laboratories, Rahway, NJ 07065, USA. |
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| Abstract: | Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described. |
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