Highly substituted pyridines via tethered imine-enamine (TIE) methodology |
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Authors: | Raw Steven A Taylor Richard J K |
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Affiliation: | Department of Chemistry, University of York, Heslington, York, UKYO10 5DD. sar113@york.ac.uk |
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Abstract: | A tethered imine-enamine methodology has been developed for the direct conversion of 1,2,4-triazines into highly substituted pyridines via the inverse electron demand Diels-Alder reaction which avoids the need for a discrete aromatisation step. This TIE methodology has also been applied in one pot reaction cascades involving 1,2,4-triazines and utilising MnO(2)-mediated tandem oxidation processes (TOPs). |
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