| 纳米CoHCF修饰电极的制备及其对血红蛋白的电化学测定研究 |
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| 引用本文： | 刘梅川,李平,张莉,鲜跃仲,丁红春,张成林,张芬芬,金利通.纳米CoHCF修饰电极的制备及其对血红蛋白的电化学测定研究[J].中国化学,2005,23(8):983-989. |
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| 作者姓名： | 刘梅川 李平 张莉 鲜跃仲 丁红春 张成林 张芬芬 金利通 |
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| 作者单位： | [1]Department of Chemistry, East China Normal University, Shanghai 200062, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of C＇hina（No. 20305007）, Doctoral Foundation of China University of Ministry of Education （No. 20030269014） and Shanghai Rising-Star Program （No. 04QMX 1421）. |
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| 摘 要： | A cobalt hexacyanoferrate （CoHCF） nanoparticle （size ca. 60 nm） chemically modified electrode （CME） was fabricated and the electrochemical behavior of hemoglobin （Hb） at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode （GCE） and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife, Combined with liquid chromatography （LC）, the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis-electrochemical determination （FIA-ECD） system. The peak current was a linear function of concentrations in the range from 2.5×10^-8 to 5.0×10^-6mol/L for Hb, with detection limit of 1.4×10^-8 mol/L. The FIA-ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample-consumption.
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| 关 键 词： | 六氰基高铁酸钴 纳米粒子 修饰电极 血色素 电解分析 医学临床分析 |
| 收稿时间： | January 5,2005 |
| 修稿时间： | January 5,2005 |
Preparation of Nanosized CoHCF Modified Electrode and Its Application to Electroanalysis of Hemoglobin |
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| Liu MeiChuan;Li Ping;Zhang Li;Xian YueZhong;Ding GongChun;Zhang ChengLin;Zhang FenFen;Jin LiTong.Preparation of Nanosized CoHCF Modified Electrode and Its Application to Electroanalysis of Hemoglobin[J].Chinese Journal of Chemistry,2005,23(8):983-989. |
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| Authors: | Liu MeiChuan;Li Ping;Zhang Li;Xian YueZhong;Ding GongChun;Zhang ChengLin;Zhang FenFen;Jin LiTong |
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| Abstract: | A cobalt hexacyanoferrate (CoHCF) nanoparticle (size ca. 60 nm) chemically modified electrode (CME) was fabricated and the electrochemical behavior of hemoglobin (Hb) at this nanosized CoHCF CME was studied. In comparison with a bare glassy carbon electrode (GCE) and a general CoHCF CME electrodeposited in a traditional manner, the present nanosized CoHCF CME performed efficiently electrocatalytic reduction for Hb with relatively high sensitivity, stability, and longlife. Combined with liquid chromatography (LC), the nanosized CoHCF CME was used as the electrochemical detector of Hb in the established flow injection analysis‐electrochemical determination (FIA‐ECD) system. The peak current was a linear function of concentrations in the range from 2.5×10‐8 to 5.0×10‐6 mol/L for Hb, with detection limit of 1.4×10‐8 mol/L. The FIA‐ECD system has been successfully applied to assess the Hb content of clinic blood samples with advantages of sensitiveness, speediness, easy control and small sample‐consumption. |
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| Keywords: | nanosized cobalt hexacyanoferrate chemically modified electrode hemoglobin direct electrochemical determination flow injection analysis-electrochemical determination clinic blood |
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