Reaction of dimethoxycarbene-DMAD zwitterion with 1,2-diones and anhydrides: a novel synthesis of highly substituted dihydrofurans and spirodihydrofurans |
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| Authors: | Nair Vijay Deepthi Ani Poonoth Manojkumar Santhamma Bindu Vellalath Sreekumar Babu Beneesh Pattoorpady Mohan Resmi Suresh Eringathodi |
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| Institution: | Organic Chemistry Division, Regional Research Laboratory (CSIR), Trivandrum, India. vijaynair_2001@yahoo.com |
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| Abstract: | The zwitterion formed by the reaction of dimethoxycarbene and DMAD adds efficiently to one of the carbonyl groups of 1,2-dicarbonyl compounds and anhydrides to generate dihydrofurans and spirodihydrofurans in good yields. In many cases, the carbene inserts into the C-C bond of the dione to yield masked vicinal tricarbonyl systems. |
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