4‐Phosphatephenyl Covalently Modified Glassy Carbon Electrode for Real‐Time Electrochemical Monitoring of Paracetamol Release from Electrospun Nanofibers |
| |
| Authors: | Guocheng Yang Lu Wang Yingshu Yang Xuesong Chen Defeng Zhou Jianbo Jia Dongfeng Li |
| |
| Affiliation: | 1. School of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, P.?R. China tel.: +86‐431‐85716671;2. fax: +86‐431‐85698041;3. Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin 150040, P.?R. China;4. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.?R. China |
| |
| Abstract: | A glassy carbon electrode (GCE) was covalently modified by 4‐phosphatephenyl (4‐PP). Sensing paracetamol (PCT) via linear sweep voltammetry in sulfuric buffer solution of pH 1.02 at 36.8 °C, the 4‐PP‐modified GCE showed high electrochemical sensitivity and long reusability. PCT‐loaded poly(vinyl alcohol) (PVA) nanofibers were prepared by electrospinning. Based on the calibration curve of PCT on the 4‐PP‐modified GCE, the PCT release process from the nanofibers was electrochemically monitored in real time via two routes. The results showed that the covalently modified GCE can be repeatedly used as real‐time electrochemical monitoring platform for drug release from drug‐loaded nanofibers in the long term. |
| |
| Keywords: | 4‐Phosphatephenyl Modified electrode Paracetamol Electrospinning Drug release |
|
|
