Stereoselective Total Synthesis of Botryolide E |
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| Authors: | Boyapati Veeranjaneyulu Malampati Srilatha Gandolla Chinna Reddy Biswanath Das |
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| Affiliation: | 1. Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500?007, India, (phone: +91‐40‐7193434;2. fax: +91‐40‐7160512) |
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| Abstract: | The stereoselective total synthesis of the naturally occurring γ‐lactone derivative botryolide E ( 1 ) was accomplished with acetaldehyde as the starting material (Scheme 2). The asymmetric allyl boration, asymmetric dihydroxylation, chelation‐mediated diastereoselective vinylation, and ring‐closing metathesis reaction are the key steps. The method can conveniently be utilized for the preparation of other related γ‐lactone derivatives. |
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| Keywords: | Botryolide E Ring closing metathesis Stereoselective synthesis |
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