Syntheses and Applications of Monofluorinated Cyclopropanes |
| |
| Authors: | Dr. Emilie David Gaëlle Milanole Pavel Ivashkin Dr. Samuel Couve‐Bonnaire Prof. Dr. Philippe Jubault Prof. Dr. Xavier Pannecoucke |
| |
| Affiliation: | INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont‐Saint‐Aignan Cedex (France), Fax: (+33)?2 35 52 29 59 |
| |
| Abstract: | The combination of a fluorine atom and a cyclopropane ring, which both possess unique structural and chemical features, can generate new relevant building blocks for the discovery of efficient fluorinated biologically active agents. In this review, we report the different strategies to access monofluorocyclopropanes and highlight some of their attractive biological applications. |
| |
| Keywords: | asymmetric synthesis carbenes cyclopropane fluorine fluoroalkenes Michael reaction |
|
|
