Yalongenes A and B,Two New Cembranoids with Cytoprotective Effects from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller |
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| Authors: | Li‐Gong Yao Hai‐Yan Zhang Lin‐Fu Liang Xian‐Jun Guo Shui‐Chun Mao Yue‐Wei Guo |
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| Institution: | 1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi‐Tech Park, Shanghai 201203, P.?R. China , (phone: +86‐21‐50805813);2. Department of Pharmacy, Nanchang University, Nanchang 330006, P.?R. China , (phone: +86‐791‐6361839) |
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| Abstract: | Two new cembranoids, yalongenes A ( 1 ) and B ( 2 ), were isolated from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller . Their structures were elucidated by detailed spectroscopic analysis (IR, MS, and NMR) and by comparison with a related model compound. Yalongenes 1 and 2 were evaluated for their cytoprotective effects on SH‐SY5Y cell injury induced by H2O2 in vitro, and the result showed that only compound 1 had a significant cytoprotective activity at the concentration of 1 μM . |
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| Keywords: | Sarcophyton trocheliophorum Cembranoids Yalongenes A and B Cytoprotective activity Soft corals |
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