Synthesis of new pyrazolone-based heterocycles as inhibitors of monoamine oxidase enzymes |
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Authors: | Taha M A Eldebss Xue-Jing Yi Ahmad M Farag Ahmad A Khedr Mohamed M Abdulla Yahia N Mabkhot |
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Institution: | 1.Department of Chemistry, Faculty of Science,Cairo University,Giza,Egypt;2.Yueyang Vocational Technical College,Yueyang,China;3.Research Unit,Saco Pharm. Co.,6th October City,Egypt;4.Department of Chemistry, College of Science,King Saud University,Riyadh,Saudi Arabia |
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Abstract: | A series of new substituted pyrazoles embedded with a variety of function groups has been synthesized from 4-4-(1,2-dihydro-2,3-dimethyl-1-phenyl-5-oxo-3H-pyrazol-4-yl)]-2-cyano-4-oxo-butanenitrile (4). The synthesized compounds were fully characterized and their structures were elucidated based on elemental analysis, spectral data, and alternative synthetic pathways, whenever possible. The pharmacological activities of these new compounds as inhibitors for of type A and type B monoamine oxidase (MAO) enzymes have been investigated and compared to the most common inhibitors of MAO enzymes used to treat depression and anxiety such as deprenyl (selegiline), moclobemide, and clorgyline drugs. The most potent of the synthesized compounds was 4, 11, and 53 which showed higher inhibition activity toward type A MAO enzyme and even exceeded that of deprenyl, moclobemide, and clorgyline drugs. |
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