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Proteasome Inhibitor Anticancer Drug Bortezomib Redox Behaviour at a Glassy Carbon Electrode |
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| Authors: | Diana Andreea Golea Victor C Diculescu Laura Tugulea Ana Maria Oliveira Brett |
| Institution: | 1. Departamento de Quimica, Universidade de Coimbra, 3004–535 Coimbra, Portugal;2. Department of Electricity, Solid State and Biophysics, Faculty of Physics, University of Bucharest, Str. Atomistilor 405, 077125, Bucharest‐Magurele, Romania;3. National Institute of Research and Development for Biological Sciences, Splaiul Independen?ei 296, district 6, 060031, Bucharest, Romania |
| Abstract: | Bortezomib is the first therapeutic proteasome inhibitor used for cancer treatment. The redox behaviour of bortezomib was investigated over a wide pH range. Bortezomib undergoes electrochemical oxidation and reduction in independent mechanisms. The oxidation of bortezomib is pH‐dependent for pH<7.5 and occurs with the transfer of one electron and one proton involving the formation of two electroactive oxidation products. The reduction of bortezomib is quasi‐reversible, pH‐dependent, involving the transfer of two electrons and two protons and does not involve the formation of electroactive products. The value of pKa≈7.5 was determined. Mechanisms for oxidation and reduction were proposed. |
| Keywords: | Bortezomib Cancer treatment Voltammetry Proteasome Inhibitor |