Abieseconordines A and B,Two Novel Norditerpenoids with a 18‐Nor‐5,10 : 9,10‐disecoabietane Skeleton from Abies forrestii |
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| Authors: | Ping Yu Shou‐De Zhang Yong‐Li Li Xian‐Wen Yang Hua‐Wu Zeng Hong‐Lin Li Wei‐Dong Zhang |
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| Affiliation: | 1. Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.?R. China (phone/fax: +86‐21‐8187‐1244);2. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.?R. China;3. Key Laboratory of Marine Bio‐resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, and RNAM Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, P.?R. China, (phone: +86‐20‐89023174;4. fax: +86‐20‐84451672);5. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, P.?R. China |
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| Abstract: | A systematic phytochemical investigation on Abies forrestii afforded two new and 20 known compounds. Abieseconordines A and B ( 1 and 2 ) are the first two examples of norditerpenes with a novel 18‐nor‐5,10 : 9,10‐disecoabietane skeleton. Their structures were established mainly by analysis of 1D‐ and 2D‐NMR spectroscopic data. In addition, electronic circular‐dichroism calculations and molecular‐orbital analysis were utilized to confirm the absolute configuration of 1 . Both compounds exhibited a potent effect in a bioassay inhibiting LPS‐stimulated NO production in RAW264.7 macrophages. |
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| Keywords: | Abies forrestii Abieseconordines A and B Electronic circular dichroism (ECD) Ditepenoids Nitric oxide Density‐functional theory (DFT) |
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