A New Prenylated Isoflavone and a New Flavonol Glycoside from Flemingia philippinensis |
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| Authors: | Manqin Fu Shixiu Feng Nenling Zhang Xiaojun Zhou Riming Huang Huijuan Huang Zhifang Xu Xu‐e Li Samuel X. Qiu |
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| Affiliation: | 1. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, P.?R. China (phone/fax: +86‐20‐37081190);2. Graduate University of Chinese Academy of Sciences, Beijing 100049, P.?R. China;3. Department of Pharmacy, Medical College, Nanchang University, Nanchang 330006, P.?R. China;4. Guangdong Provincial Key Lab of Biotechnology for Plant Development, South China Normal University. Guangzhou 510631, P.?R. China |
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| Abstract: | A new prenylated isoflavonoid, flemiphilippinin G ( 1 ), and a new flavonol glycoside, flemiphilippininside ( 2 ), along with eleven known isoflavonoids were obtained from the roots of Flemingia philippinensis (Merr. et Rolfe) Li . Their structures were elucidated on the basis of spectroscopic data. The in vitro cytotoxicities of compounds 1 – 13 against MCF‐7, A549, and Hep‐G2 cell lines were determined by using the MTT (=3‐(4,5‐dimethylthazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide) colorimetric assay, and their antioxidant activities were evaluated by ferric‐reducing antioxidant power (FRAP) method. Compound 1 exhibited significant cytotoxicity against all the tested cell lines with IC50 values of 4.8–7.3 μM , and compound 2 was found to be inactive. Both compounds 1 and 2 showed weak antioxidant activities with FRAP values of 110±15 and 124±16 μmol/g, respectively. |
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| Keywords: | Flemingia philippinensis Isoflavonoids Flavonol glycosides Flemiphilippinin G Flemiphilippininside Glycosides |
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