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Designing and Synthesis of Novel Amidated Fentanyl Analogs |
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| Authors: | Yaghoub Haghighatnia Saeed Balalaie Hamid Reza Bijanzadeh |
| Institution: | 1. Peptide Chemistry Research Center, K.?N. Toosi University of Technology, P.O. Box 15875‐4416, Tehran, Iran (phone: +98‐21‐22886575;2. fax: +98‐21‐22853650);3. Department of Chemistry, Tarbiat Modares University, P.O. Box 141115‐175, Tehran, Iran |
| Abstract: | Some new amidated fentanyl (=N‐1‐(2‐phenylethyl)piperidin‐4‐yl]‐N‐phenylpropanamide) analogs with a 4‐(N‐phenylamido)piperidine scaffold and additional amide bonds have been designed and synthesized through Ugi four‐component reaction (Ugi‐4CR). Good‐to‐high yields, diversity‐oriented synthesis, and possible applications in drug discovery are advantages of this approach. |
| Keywords: | Fentanyl analogs Ugi reaction Amides Drug discovery Diversity‐oriented synthesis Multicomponent reactions |