Four New Cuparene‐Type Sesquiterpenes from Flammulina velutipes |
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| Authors: | Ya‐Qi Wang Li Bao Xiao‐Li Yang Huan‐Qin Dai Hui Guo Xin‐Sheng Yao Li‐Xin Zhang Hong‐Wei Liu |
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| Affiliation: | 1. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, P.?R. China (phone/fax: +86‐20‐85225849);2. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 9 Beiertiao, Zhongguancun, Haidian District, Beijing 100190, P.?R. China (phone/fax: +86‐10‐62566577);3. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, No.?9 Beiertiao, Zhongguancun, Haidian District, Beijing 100090, P.?R. China |
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| Abstract: | Flamvelutpenoids A–D ( 1 – 4 ), four new cuparene‐type sesquiterpenes, were isolated from the solid culture of Flammulina velutipes. Their structures were elucidated by NMR experiments. The absolute configurations of 1 and 2 were assigned via the circular dichroism data of the [Rh2(OCOCF3)4] complex, whereas that of C(3) of 3 was determined by applying the octant rule for the α,β‐unsaturated ketone moiety. Compounds 1 – 4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and methicillin‐resistant Staphylococcus aureus with MIC values larger than 100 μM . |
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| Keywords: | Flammulina velutipes Flamvelutpenoids A – D Antibacterial activity Fungi Cuparene‐type sesquiterpenes Sesquiterpenes |
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