One‐Pot Four‐Component Synthesis of N2‐Alkyl‐N3‐[2‐(1,3,4‐oxadiazol‐2‐yl)aryl]benzofuran‐2,3‐diamines |
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| Authors: | Mehdi Adib Ehsan Sheikhi Morteza Karimzadeh Hamid Reza Bijanzadeh Massoud Amanlou |
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| Affiliation: | 1. School of Chemistry, University College of Science, University of Tehran, P.O. Box 14155?–?6455, Tehran, Iran (phone/fax: +98‐21‐66495291);2. Department of Chemistry, Tarbiat Modares University, P.O. Box 14115‐175, Tehran, Iran;3. Pharmaceutical Sciences Research Center and Department of Medicinal Chemistry, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | A simple synthesis of N2‐alkyl‐N3‐[2‐(1,3,4‐oxadiazol‐2‐yl)aryl]benzofuran‐2,3‐diamines 5 via a one‐pot four‐component reaction is described (Scheme 1). A mixture of N‐(isocyanoimino)triphenylphosphorane ( 1 ), a 2‐aminobenzoic acid 2 , a 2‐hydroxybenzaldehyde 3 , and an isocyanide 4 in absolute EtOH at room temperature undergoes a smooth reaction to afford 5 in excellent yields (Table). |
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| Keywords: | Benzofuran‐2,3‐diamines Multicomponent reactions |
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