Electrochemical Oxidation of Catechols (=Benzene‐1,2‐diols) in the Presence of Benzoylacetonitrile: Synthesis of New Derivatives of 5,6‐Dihydroxybenzofuran |
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Authors: | Davood Nematollahi Ali Reza Atlasi‐Pak Roya Esmaili |
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Affiliation: | 1. Faculty of Chemistry, Bu‐Ali Sina University, Hamedan, Zip Code 65178‐38683, Iran, (phone: +98‐811‐8380647;2. fax: +98‐811‐8380709) |
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Abstract: | The electrochemical oxidation of catechol (=benzene‐1,2‐diol; 1a ) and some of its derivatives in H2O/MeCN 1 : 1 containing benzoylacetonitrile (=β‐oxobenzenepropanenitrile; 3 ) as a nucleophile was studied by cyclic voltammetry and controlled‐potential coulometry. The voltammetric data showed that electrochemically generated o‐benzoquinones (=cyclohexa‐3,5‐diene‐1,2‐diones) from catechol ( 1a ) and 3‐methylcatechol ( 1b ) participate in a Michael‐addition reaction with 3 to form the corresponding 5,6‐dihydroxybenzofuran‐3‐carbonitrile 8 (Scheme 1). In this work, we report an efficient one‐pot method with high atom economy for the synthesis of new substituted 5,6‐dihydroxybenzofuran‐3‐carbonitriles in an undivided cell under ambient conditions. |
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Keywords: | Catechol Benzoylacetonitrile Dihydroxybenzofuran derivatives Electrochemical oxidation |
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