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Two New Diterpenoids and Other Constituents from Isodon japonicus
Authors:Rui‐Jie Hou  Fu‐Lin Yan  Hai‐Yang Zhang  Yi‐Xiao Bai  Ming‐Ming Ding
Affiliation:1. Pharmacy College, Xinxiang Medical University, Xinxiang 453003, P.?R. China, (phone: +86‐13782513326;2. fax: +86‐373‐3029882);3. First Clinical College of Xinxiang Medical University, Weihui 453100, P.?R. China
Abstract:Two new ent‐kaurene diterpenoids, 15α,20‐dihydroxy‐6,7‐seco‐entkaur‐16‐ene‐7,1α(6,11α)‐diolide ( 1 ), 6β‐butyroxy‐3β‐hydroxy‐6,7‐seco‐6,20‐epoxy‐7,1α‐olide‐entkaur‐16‐en‐15‐one ( 2 ), together with 25 known compounds, 3 – 27 , were isolated from the leaves of Isodon japonicus. Their structures were established by spectroscopic methods, including 2D‐NMR techniques.
Keywords:Isodon japonicus  ent‐Kaurane diterpenoids  Diterpenoids
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