A Manifold Three‐Step Synthetic Route to Polycyclic Annulated Hydantoins via Cyclic Imines |
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| Authors: | Fabian Brockmeyer Denis Kröger Timo Stalling Pasqual Ullrich Jürgen Martens |
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| Institution: | 1. Institut für Reine und Angewandte Chemie der Carl von Ossietzky Universit?t Oldenburg, Carl‐von‐Ossietzky‐Str. 9?–?11, D‐26129 Oldenburg, (phone: +49‐441‐798‐3837;2. fax: +49‐441‐798 3329) |
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| Abstract: | A new three‐step synthetic pathway to generate polycyclic annulated hydantoins via rarely investigated heterocyclic imines is described. This procedure includes a one‐pot reaction forming imines as precursor structures (e.g., Asinger reaction), followed by an Ugi reaction to build up a bisamide structure that allows a ring‐closing reaction to the targeted hydantoins via substitution. This pathway leads to a multiplicity of substances with a potential pharmacological activity. |
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| Keywords: | Asinger reaction Hydantoins Imines Multicomponent reaction Ugi reaction |
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