Highly Acetylated Lanostane‐Type Triterpenoids from Coprinus cinereus 120 |
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| Authors: | Yuan‐Zhen Liu Yao‐Yao Li Yi‐Fei Sun Zhong‐Hui Zheng Si‐Yang Song Wen‐Jin Su Yue‐Mao Shen |
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| Institution: | 1. Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering;2. Xiamen Engineering Research Center of Marine Microbial Drug Discovery;3. Fujian Engineering Laboratory for Pharmaceuticals;4. School of Life Sciences, Xiamen University, Xiamen 361005, P.?R. China;5. State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University, No. 27 South Shanda Road, Jinan 250100, P.?R. China;6. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P.?R. China (phone/fax: +86‐531‐88382108) |
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| Abstract: | Two new highly acetylated lanostane‐type triterpenoids, coprinacin A ( 1 ) and coprinacin B ( 2 ), were isolated from the basidiomycetous strain Coprinus cinereus 120. The chemical structures of 1 and 2 were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments and FT‐ICR‐MS, and their in vitro cytotoxic activities against the human‐tumor cell line HeLa were established as modest. |
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| Keywords: | Coprinus cinereus Coprinacins A and B Cytotoxic activity Triterpenoids Lanostane‐type triterpenoids |
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