Total Synthesis,Absolute Configuration,and Biological Activity of Xyloallenoide A |
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| Authors: | San‐Yong Wang Zhong‐Liang Xu Hui Wang Chun‐Rong Li Li‐Wu Fu Ji‐Yan Pang Jing Li Zhi‐Gang She Yong‐Cheng Lin |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Sun Yat‐sen University, 135 Xingang West Road, Guangzhou 510275, P.?R. China (phone/fax: +86‐20‐84039623);2. Guangdong Food Industry Institute, Guangzhou 510308, P.?R. China;3. School of Chemistry and Environment, South China Normal University, Guangzhou 510006, P.?R. China |
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| Abstract: | The novel natural product xyloallenoide A, isolated from the marine mangrove endophytic fungus from the South China Sea, and its diastereoisomer xyloallenoide A1, which contain N‐methyl‐substituted amino acids, were synthesized. The absolute configurations of the amino acid units of xyloallenoide A were finally confirmed to be L ‐Lys, Me‐D ‐Val, and Me‐L ‐Ala. This report represents a practical and attractive alternative for the synthesis of N‐methyl‐substituted cyclotripeptides. In the preliminary bioassay, synthetic xyloallenoide A showed marginal activities against KB (IC50=9.6 μM ) and KBv200 cells (IC50=10.3 μM ), and xyloallenoide A1 was inactive against KB and KBv200 cells. |
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| Keywords: | Xyloallenoides A and A1 Cyclopeptides Cytotoxic activity |
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