Green chemical multicomponent approach for the synthesis of C3-pyranopyrazole-substituted coumarins |
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| Authors: | Venkata Swamy Tangeti Kattaru Ramesh Babu G. V. Siva Prasad Tadikonda Ramu C. Venkata Rao |
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| Affiliation: | 1.Raghu Engineering College (Affiliated to JNTU Kakinada),Visakhapatnam,India;2.Vector Control Research Centre (Indian Council of Medical Research),Puducherry,India;3.Sri Venkateswara University,Tirupathi,India |
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| Abstract: | An efficient and rapid method was developed for the synthesis of C3-pyranopyrazole-substituted coumarins from one-pot five-component reaction of β-keto ester, hydrazine, O-hydroxy aromatic aldehydes, 6-methyl, 4-hydroxy pyranone and aromatic aldehyde in the presence of tri-ethylamine in solvent-free conditions. The microwave-assisted method reported herein offers advantageous shorter reaction times, higher yields and cleaner reaction compared with conventional heating methods. |
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