Synthesis of a C‐Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866 |
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| Authors: | Annabelle Gillig Somi Reddy Majjigapu Bernard Sordat Pierre Vogel |
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| Affiliation: | 1. Laboratory of Glycochemistry and Asymmetric Synthesis (LGSA), Swiss Institute of Technology in Lausanne (EPFL), Batochime, CH‐1015 Lausanne, (phone: +41?21?693?93?71;2. fax: +41?21?693?93?75) |
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| Abstract: | FK866 (also named APO866 or WK175) is a potent NAMPT inhibitor being evaluated (Phase II) as a potential anticancer drug. The preparation of the C‐iminoribofuranoside analog (2E)‐N‐[4‐(1‐benzoylpiperidin‐4‐yl)butyl]‐3‐{3‐[(2S,3S,4R,5R)‐3,4‐dihydroxy‐5‐(hydroxymethyl)pyrrolidin‐2‐yl]phenyl}prop‐2‐enamide ((?)‐ 1 ) is reported. |
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| Keywords: | Ribofuranoside analogs, C‐imino‐ FK866 Nicotinamide phosphoribosyltransferase Inhibitors |
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