Efficient One‐Pot Synthesis of Alkyl 2‐(Dialkylamino)‐4‐phenylthiazole‐5‐carboxylates and Single‐Crystal X‐Ray Structure of Methyl 2‐(Diisopropylamino)‐4‐phenylthiazole‐5‐carboxylate |
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| Authors: | Ali Souldozi Ali Ramazani Ali Reza Dadrass Katarzyna ?lepokura Tadeusz Lis |
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| Institution: | 1. Department of Chemistry, Urmia Branch, Islamic Azad University, P.O. Box 969, Urmia, Iran, (fax: +98‐441‐3453371);2. Department of Chemistry, Zanjan Branch, Islamic Azad University, P.O. Box 49195‐467, Zanjan, Iran, (fax: +98‐241‐4261221);3. Department of Chemistry, Faculty of Science, Urmia University, P.O. Box 57159‐165, Urmia, Iran;4. Faculty of Chemistry, University of Wroc?aw, 14 Joliot‐Curie St., PL‐50‐383 Wroc?aw |
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| Abstract: | The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (=dialkyl but‐2‐ynedioates) in the presence of silica gel (SiO2) led to alkyl 2‐(dialkylamino)‐4‐phenylthiazole‐5‐carboxylates in fairly high yields. The structures of the products were confirmed by their IR, 1H‐ and 13C‐NMR, and mass spectra, and by a single‐crystal X‐ray structure determination. |
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| Keywords: | Thiazole‐5‐carboxylates alkyl 2‐(diarylamino)‐4‐phenyl‐ Multicomponent reactions X‐Ray crystallography |
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