The First Stereoselective Total Synthesis of a Naturally Occurring Bioactive Diarylheptanoid, (3R,6E)‐1,7‐Bis(4‐hydroxyphenyl)hept‐6‐en‐3‐ol,through Two Different Approaches |
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Authors: | Jajula Kashanna Paramesh Jangili Rathod Aravind Kumar Biswanath Das |
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Affiliation: | 1. Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500?007, India, (phone: +91‐40‐7193434;2. fax: +91‐40‐7160512) |
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Abstract: | The stereoselective total synthesis of a naturally occurring bioactive diarylheptanoid, (3R,6E)‐1,7‐bis(4‐hydroxyphenyl)hept‐6‐en‐3‐ol, has been accomplished starting from 4‐hydroxybenzaldehyde through two different approaches involving Wittig olefination, hydrolytic kinetic resolution of a racemic epoxide, and olefin cross‐metathesis reaction as the key steps. |
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Keywords: | Stereoselective synthesis Heptanoid, diaryl‐ Wittig olefination Kinetic resolution Total synthesis |
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