Highly Concise and Stereoselective Total Synthesis of (5R,7S)‐Kurzilactone |
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| Authors: | Debendra K Mohapatra Pulluri Karthik Jhillu S Yadav |
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| Institution: | 1. Natural Products Chemistry Division, CSIR‐Indian Institute of Chemical Technology, Hyderabad‐500007, India (phone: +91‐40‐27193128;2. fax: +91‐40‐27160512) |
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| Abstract: | A highly concise and stereoselective total synthesis of (5R,7S)‐kurzilactone ( 1 ) was performed by a convergent approach by means of a Jacobsen's hydrolytic kinetic resolution, a Horner? Wadsworth? Emmons reaction for the construction of the α,β‐unsaturated δ‐lactone ring system, and a highly diastereoselective Mukaiyama aldol reaction for the introduction of the formal anti‐1,3‐diol unit (Schemes 2 and 3). |
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| Keywords: | (5R 7S)‐Kurzilactone Jacobsen's hydrolytic kinetic resolution Horner?Wadsworth?Emmons reaction Mukaiyama aldol reaction |
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