A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target |
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| Authors: | Prof?Dr Peter Faller Dr Christelle Hureau |
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| Institution: | 1. CNRS, LCC (Laboratoire de Chimie de Coordination), 205 route de Narbonne, BP 44099, 31077 Toulouse Cedex 4 (France), Fax: (+33)?5‐61‐55‐30‐03;2. Université de Toulouse, UPS, INPT, 31077 Toulouse Cedex 4 (France) |
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| Abstract: | Metal ions Cu, Zn and Fe, seem to play a pivotal role in Alzheimer’s disease and other neurodegenerative diseases. In order to understand this in a broader sense, one has to considerer the peculiarities of metal metabolism in the brain compared to most other tissues, as well as the importance of the redox active metal ions, Fe and Cu, in oxygen metabolism and the connected oxidative stress. |
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| Keywords: | Alzheimer’ s disease amyloid beta peptides bioinorganic chemistry neurochemistry transition metals |
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