New Quinic Acid Derivatives from Hepatoprotective Inula crithmoides Root Extract |
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| Authors: | Maha A. Aboul Ela Abdalla M. El‐Lakany Maged S. Abdel‐Kader Saleh I. Alqasoumi Safa M. Shams‐El‐Din Hala M. Hammoda |
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| Affiliation: | 1. Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon;2. Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia;3. Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt, (phone: +20101218356;4. fax: +2034873273) |
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| Abstract: | Fractionation directed by hepatoprotective activity of Inula crithmoides L. root resulted in the isolation of two new quinic acid derivatives, 3,5‐di‐O‐caffeoylquinic acid 1‐methyl ether ( I ; caffeoyl=(E)‐3‐(3,4‐dihydroxyphenyl)prop‐2‐enoyl; quinic acid=1,3,4,5‐tetrahydroxycyclohexanecarboxylic acid) and 4,5‐di‐O‐caffeoylquinic acid 1‐methyl ether ( II ), in addition to the well‐known hepatoprotective compound, 1,5‐di‐O‐caffeoylquinic acid ( III ). The hepatoprotective effect was indicated by the significant decrease in the level of four measured serum biochemical parameters (SGOT, SGPT, ALP, and bilirubin) in experimental rats. The structures of the isolated compounds were determined by analyses of 1D‐ and 2D‐NMR spectroscopic data. |
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| Keywords: | Inula crithmoides Hepatoprotective activity Quinic acid |
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