Alkaloid and Anthraquinone Derivatives Produced by the Marine‐Derived Endophytic Fungus Eurotium rubrum |
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Authors: | Hui‐Jiao Yan Xiao‐Ming Li Chun‐Shun Li Bin‐Gui Wang |
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Institution: | 1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, P.?R. China (phone: +86‐532‐82898553;2. fax: +86‐532‐82880645);3. Graduate School of the Chinese Academy of Sciences, Beijing 100049, P.?R. China |
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Abstract: | Cultivation of the fungal strain Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of the semi‐mangrove plant Hibiscus tiliaceus, resulted in the isolation of one new dioxopiperazine alkaloid, 12‐demethyl‐12‐oxo‐eurotechinulin B ( 1 ), and one new anthraquinone derivative, 9‐dehydroxyeurotinone ( 2 ), together with ten known compounds including variecolorin J ( 3 ), eurotechinulin B ( 4 ), variecolorin G ( 5 ), alkaloid E‐7 ( 6 ), cryptoechinuline G ( 7 ), isoechinulin B ( 8 ), 7‐isopentenylcryptoechinuline D ( 9 ), 2‐O‐methyl‐9‐dehydroxyeurotinone ( 10 ), emodin ( 11 ), and emodic acid ( 12 ). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature reports. Some of the purified compounds were evaluated for antibacterial, antifungal, and cytotoxic activities. |
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Keywords: | Hibiscus tiliaceus Eurotium rubrum Eurotechinulin B 12‐demethyl‐12‐oxo‐ 9‐Dehydroxyeurotinone Antibacterial activity Cytotoxic activity Antifungal activity |
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