Proteomics Approach to Investigate Impact of aFGF Antagonist on Signal Transduction Pathway |
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| Authors: | FU Yu-qin LI Min WANG Xu ZHOU Guo-qiang ZHOU Hui CUI Yin-qiu |
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| Institution: | [1]Biomacromolecular Laboratory [2]Key Lab of Molecular Enzymology Engineening, Ministry of Education, College of Life Science, Jilin University, Changchun 130021, P. R. China [3]College of Life Science, Jilin Agricultural University, Changchun 130118, P. R. China |
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| Abstract: | Fibroblast growth factor(FGF) signal transduction pathway is correlated with many diseases,such as cancer,skeletal dysplasias,olfactory syndromes and so on.P(VYMSPF),a small peptide,is an antagonist of aFGF.In order to investigate the impact of the peptide P on aFGF signal transduction pathway,the proteomes of NIH3T3 cell stimulated under different conditions(aFGF+heparin sodium and aFGF+heparin sodium+P) were extracted and analyzed by 2DE,five differentially expressed protein spots were selected and identi... |
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| Keywords: | Proteomics aFGF Signal transduction pathway |
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