PHOTODEGRADATION OF THE IMIDAZOLE RING INDUCED BY INDOLE DERIVATIVES IN OXYGEN-FREE AQUEOUS SOLUTIONS |
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| Authors: | C Hasselmann C Pigault R Santus † G Laustriat ‡ |
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| Institution: | *Laboratoire de Biophysique, Universite Louis Pasteur, U.E.R. des Sciences pharmaceutiques, Equipe de Recherche AssociCe au C.N.R.S. (No. 551), 67083 Strasbourg Cedex, France;†Laboratoire de Biophysique, Museum National d'Histoire Naturelle, 61;, rue Buffon, 75005 Paris, France |
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| Abstract: | Abstract— An imidazole ring photodegradation induced by indole derivatives in oxygen-free aqueous solutions (Λexc= 254 nm) was demonstrated and studied in various systems at low concentration (0.2 m M ). The degradation rate was maximal in the indole-imidazole system and decreased when a substituent was present on either or both rings. The degradation rate also depended on pH (maximal at pH ˜ 6) and on imidazole concentration. Results obtained under N2O atmosphere, in the presence and absence of 1 M t -butanol, indicate that the imidazole degradation is promoted by hydrated electrons photogenerated by the indole chromophore. Kinetic analysis of the data confirms this mechanism. |
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