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Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients |
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| Authors: | JE Mason BT Denton ND Shah SA Smith |
| Institution: | 1. Edward P. Fitts Department of Industrial & Systems Engineering, North Carolina State University, 111 Lampe Drive, Raleigh, NC 27613, USA;2. Division of Health Care Policy & Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA;3. Division of Endocrinology, Diabetes, Nutrition, & Metabolism, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA |
| Abstract: | We present a Markov decision process (MDP) model to determine the optimal timing of blood pressure and cholesterol medications. We study the use of our model for a high-risk population of patients with type 2 diabetes; however, the model and methods we present are applicable to the general population. We compare the optimal policies based on our MDP to published guidelines for initiation of blood pressure and cholesterol medications over the course of a patient’s lifetime. We also present a bicriteria analysis that illustrates the trade off between quality-adjusted life years and costs of treatment. |
| Keywords: | OR in medicine Markov decision process Type 2 diabetes Blood pressure treatment Cholesterol treatment |
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