Saracoside: a new lignan glycoside from Saraca indica, a potential inhibitor of DNA topoisomerase IB |
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Authors: | Mukherjee Tulika Chowdhury Sayan Kumar Ashish Majumder Hemanta K Jaisankar Parasuraman Mukhopadhyay Sibabrata |
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Institution: | Chemistry Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata -700032, India. |
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Abstract: | Chemical investigation of the stem bark of Saraca indica has resulted in the isolation of a new lignan glycoside, saracoside, along with four known lignan glycosides lyoniside, icariside E3, (+)5'-methoxyisolarciresinol-9'-O-beta-D-glucopyranoside and nudiposide, and a phenolic glucopyranoside, 3,4,5-trimethoxyphenyl-beta-D-glucopyranoside, which has been isolated for the first time from this species. The isolated lignan glycosides exhibit potent DNA topoisomerase IB inhibitory activity. |
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