Synthesis of taxane ABC tricyclic skeleton from lycoctonine |
| |
| Authors: | Liang Xiao-Xia Tang Pei Chen Qiao-Hong Wang Feng-Peng |
| |
| Institution: | Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, Sichuan, PR China 610041. |
| |
| Abstract: | A new conversional synthesis of the ABC ring system of taxoids from the C19-diterpenoid alkaloid lycoctonine was developed in 6 steps with 2% overall yield. The distinctive features of the conversion include pinacol rearrangement, enlargement of ring B, and opening of a four-membered ring. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
