A new antimycobacterial furanolignan from Leucophyllum frutescens |
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| Authors: | Alanís-Garza Blanca Salazar-Aranda Ricardo Ramírez-Durón Rosalba Garza-González Elvira Waksman de Torres Noemí |
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| Institution: | Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo León, P.O. Box 2316, Sucursal Tecnológico, Monterrey, N.L., 64841 México. |
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| Abstract: | Bioassay-guided fractionation of the minor active fractions obtained from the root bark of Leucophyllumfrutescens (Berl.) I. M. Johnst. led to isolation from the n-hexane extract of a new compound with moderate activity against the H37Rv Mycobacterium tuberculosis strain (MIC 63 microg/mL), and low cytotoxicity, as shown by the IC5o against Vero cells. The compound was identified by 1D/2D NMR spectroscopy a s2',5"-dimethoxysesamin. |
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